Thionyl Chloride → 2,3,5,6-Tetrafluorobenzoyl Chloride

HRID 1722033

Reaktionsgleichung

Reaktionsgleichung von HRID 1722033
[F:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([F:12])=[C:7]([F:13])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:16])=O>>[Cl:16][C:4]([C:3]1[C:2]([F:1])=[C:10]([F:11])[CH:9]=[C:8]([F:12])[C:7]=1[F:13])=[O:5]

Komponenten

3

Edukt 2

HCID 24386Thionyl Chloride2×HCID 5675332,3,5,6-Tetrafluorobenzoic Acid

Produkt 1

HCID 27340282,3,5,6-Tetrafluorobenzoyl Chloride

Versuchsvorschrift

A mixture of 2,3,5,6-tetrafluorobenzoic acid (25 g) and thionyl chloride (40 cm3) was heated at the reflux temperature for 3 hours after which the excess thionyl chloride was removed by evaporation under reduced pressure to leave a residue of 1-chlorocarbonyl-2,3,5,6-tetrafluorobenzene. To this was added an excess of dry methanol and the mixture stirred for one hour at the ambient temperature. Removal of excess methanol by evaporation under reduced pressure gave methyl 2,3,5,6-tetrafluorobenzoate (19 g) as a mobile liquid.

Aufarbeitung

  1. customwas removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d2fa710f386d43c3b0960f8f8fe28e5f
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04853414

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