Triphenylphosphine → (tert-Butoxycarbonylmethyl)triphenylphosphonium Bromide

HRID 1722232Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1722232
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>C1C=CC=CC=1>[Br-:20].[C:22]([CH2:21][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]

Komponenten

4

Edukt 2

HCID 11776TriphenylphosphineHCID 79177tert-Butyl bromoacetate

Produkt 1

HCID 2733853(tert-Butoxycarbonylmethyl)triphenylphosphonium BromideAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

A solution of triphenylphosphine (33.8 g, 129 mmol) and t-butyl bromoacetate (25 g, 128.2 mmol) in dry benzene (150 ml) was stirred for 16 hours at room temperature. The precipitated product was collected by filtration, washed with dry ether and dried in vaco to give 56 g (96% of theory) of carbo-t-butoxymethyl triphenylphosphonium bromide.

Aufarbeitung

  1. filtrationThe precipitated product was collected by filtration
  2. washwashed with dry ether
  3. customdried in vaco

Quellen und Nachweise

ORD-Eintrag
ord-b5d2fac81ff3499d9df07ea72bbc78c3
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04855086

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