P-Anisidine → N-(4-methoxyphenyl)pyridin-4-amine

HRID 1722309

Reaktionsgleichung

Reaktionsgleichung von HRID 1722309
Cl.[Cl-].[N:3]1[CH:8]=[CH:7][CH2+:6]=[CH:5][CH:4]=1.[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1>N1C=CC=CC=1>[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:6]2[CH:7]=[CH:8][N:3]=[CH:4][CH:5]=2)=[CH:13][CH:12]=1

Komponenten

3

Edukt 1

HCID 7732P-Anisidine

Produkt 1

HCID 3628677N-(4-methoxyphenyl)pyridin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A mixture of 1-(4-pyridinium chloride hydrochloride (10.0 g, 0.04 mol) and p-anisidine (4.9 g, 0.04 mol) is heated at 150° C. until the pyridine stops distilling. The resulting black oil is allowed to cool to room temperature during which time it solidifies. The solid is broken into a powder and repeatedly washed with acetone until the color is light brown. Recrystallization from isopropanol gives the product as a yellow powder, mp 129°-134° C.

Aufarbeitung

  1. distillationstops distilling
  2. washrepeatedly washed with acetone until the color
  3. customRecrystallization from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-b6f1077f4f4d41a0bf24dc5dcf64fa4f
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04855308

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