Acetyl chloride → 1-Acetyl-5-amino-3-benzylthio-1,2,4-triazole

HRID 1722930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1722930
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([S:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.C(N(CC)CC)C.[C:22](Cl)(=[O:24])[CH3:23].[OH-].[Na+]>C(Cl)Cl>[C:22]([N:6]1[C:2]([NH2:1])=[N:3][C:4]([S:7][CH2:8][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[N:5]1)(=[O:24])[CH3:23]

Komponenten

6

Edukt 4

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 7372725-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine

Produkt 1

HCID 142551221-Acetyl-5-amino-3-benzylthio-1,2,4-triazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To 30 g (0.145 mol) 5-amino-3-benzylthio-1H-1,2,4-triazole and 25 ml triethylamine in 300 ml methylene chloride, 12.57 g (0.16 mol) acetyl chloride in 30 ml methylene chloride was added dropwise. It was then stirred at room temperature for 30 minutes, treated with 160 ml 1N caustic soda and the product extracted with methylene chloride. After drying it was recrystallised from ethyl acetate.

Aufarbeitung

  1. extractionthe product extracted with methylene chloride
  2. customAfter drying it
  3. customwas recrystallised from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-750e84dd79d44b36b62808683548c0fc
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04859231

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