Trifluoroacetic acid → 4-(2-Chlorophenylamino)-5,6-difluoro-1,2-dihydroindazol-3-one

HRID 1723694Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1723694
COC(=O)[C:4]1[C:9]([NH:10][NH:11][C:12](OC(C)(C)C)=[O:13])=[CH:8][C:7]([F:19])=[C:6]([F:20])[C:5]=1[NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[Cl:28].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[NH:21][C:5]1[C:6]([F:20])=[C:7]([F:19])[CH:8]=[C:9]2[C:4]=1[C:12](=[O:13])[NH:11][NH:10]2

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 865985976-(N'-tert-Butoxycarbonylhydrazino)-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid methyl ester

Produkt 1

HCID 674033074-(2-Chlorophenylamino)-5,6-difluoro-1,2-dihydroindazol-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

6-(N′-tert-Butoxycarbonylhydrazino)-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid methyl ester (1.00 equivalent) is treated with a 1:1 mixture of methylene chloride and TFA and stirred for 2 hours The reaction mixture is concentrated under reduced pressure and the product is purified by trituration or flash column chromatography if needed.

Aufarbeitung

  1. concentrationis concentrated under reduced pressure
  2. customthe product is purified by trituration or flash column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-f465b05b652b48fc9d63acece16c8913
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07485643B2

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