Trifluoroacetic acid → HCID 69081364, Verbindung

HRID 1724722Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1724722
C(OC([N:8]1[C@@H:12]([C:13]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22](=[O:24])[CH3:23])=[CH:18][CH:17]=2)=[O:14])[CH2:11][O:10]C1(C)C)=O)(C)(C)C.[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30]>ClCCl>[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[NH2:8][C@H:12]([CH2:11][OH:10])[C:13]([O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22](=[O:24])[CH3:23])=[CH:18][CH:17]=1)=[O:14]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 690818704-acetylphenyl 3-tert-butoxycarbonyl-2,2-dimethyloxazolidine-4-(R)-carboxylate

Produkt 1

HCID 69081364HCID 69081364, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Under nitrogen, 4-acetylphenyl 3-tert-butoxycarbonyl-2,2-dimethyloxazolidine-4-(R)-carboxylate (440 mg) is dissolved in dichloromethane (15 ml), and trifluoroacetic acid (TFA; 8 ml) is added. After being subjected to agitation for 1 hour, the reaction mixture is concentrated and ether is added. The formed precipitate is filtered, then vacuum dried to obtain the desired product as a white powder (280 mg). Melting point: 115-118° C.

Aufarbeitung

  1. concentrationthe reaction mixture is concentrated
  2. additionether is added
  3. filtrationThe formed precipitate is filtered
  4. customvacuum dried

Quellen und Nachweise

ORD-Eintrag
ord-eaf5fcd2fbbd400187d408b2463c3d05
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07488755B2

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