HCID 178494656, Verbindung → HCID 178494542, Verbindung
Reaktionsgleichung
COC([C:5]1[C:6]([CH2:26][O:27][CH3:28])=[N:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:16]1[C:21]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:19]=[CH:18][N:17]=1)[N:9]=2)=O>Cl>[CH3:28][O:27][CH2:26][C:6]1[CH:5]=[C:14]([OH:15])[C:13]2[C:8](=[N:9][C:10]([C:16]3[C:21]([C:22]([F:25])([F:23])[F:24])=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:11][CH:12]=2)[N:7]=1Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 110 °C
Versuchsvorschrift
4-Hydroxy-2-methoxymethyl-7-(3-trifluoromethyl-pyridin-2-yl)-[1,8]napthyridine-3-carboxylic acid methyl ester (200 mg, 0.508 mmol) is dissolved in 12 M HCl (20 mL) and heated at 110° C. for 6 hours. The reaction mixture is poured onto ice (100 g) and extracted with CH2Cl2 (4×150 mL). The combined organic extracts are dried over Na2SO4 and the solvent removed under reduced pressure. The crude product is purified by silica gel preparatory TLC eluting with hexanes/acetone (3:1) yielding the title compound as a white solid.