Piperidine → HCID 178486868, Verbindung

HRID 1725140Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1725140
[NH:1]1CCCC[CH2:2]1.[NH2:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([OH:19])=[CH:13][C:9]=1[C:10](O)=[O:11].N1C=CC=NN=1>CO>[CH3:18][O:17][C:15]1[CH:16]=[C:8]2[C:9]([C:10]([OH:11])=[N:1][CH:2]=[N:7]2)=[CH:13][C:14]=1[OH:19]

Komponenten

5

Edukt 3

HCID 8082PiperidineHCID 1230471,2,3-TriazineHCID 198070282-Amino-5-hydroxy-4-methoxybenzoic acid

Produkt 1

HCID 178486868HCID 178486868, VerbindungAusbeute 107,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Piperidine (3 mL, 31 mmol) was added to a mixture of 2-Amino-5-hydroxy-4-methoxy-benzoic acid (8.1 g, 44.26 mmol) and triazine (5.38 g, 66.4 mmol) in MeOH (60 mL). The reaction was then heated to reflux and stir for 6 hours. The reaction was cool to 0oC. The product was isolated by filtration and washed with cold MeOH to give 6.37 g (33.2 mmol, 75%) of desired product.

Aufarbeitung

  1. temperatureThe reaction was then heated
  2. temperatureto reflux
  3. temperatureThe reaction was cool to 0oC
  4. customThe product was isolated by filtration
  5. washwashed with cold MeOH

Quellen und Nachweise

ORD-Eintrag
ord-ca545d2dde784ebba67ecf244d8b47e0
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07488823B2

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