1,4-Dioxane hydrochloride → 1-(3-Chloro-2-fluorobenzoyl)piperazine hydrochloride

HRID 1725503Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1725503
[Cl:1][C:2]1[C:3]([F:23])=[C:4]([CH:20]=[CH:21][CH:22]=1)[C:5]([N:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1)=[O:6].Cl.O1CCOCC1>CO>[ClH:1].[Cl:1][C:2]1[C:3]([F:23])=[C:4]([CH:20]=[CH:21][CH:22]=1)[C:5]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)=[O:6]

Komponenten

4

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57562582Tert-butyl 4-(3-chloro-2-fluorobenzoyl)piperazine-1-carboxylate

Produkt 1

HCID 686779601-(3-Chloro-2-fluorobenzoyl)piperazine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a mixture of 35.1 g of tert-butyl 4-(3-chloro-2-fluorobenzoyl)piperazine-1-carboxylate and 50 ml of methanol was added a hydrochloric acid-1,4-dioxane solution (4 M, 100 ml) followed by stirring at room temperature for 2.5 hours. The reaction mixture was concentrated in vacuo and the residue was suspended in diethyl ether, filtered and collected to give the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. filtrationfiltered
  3. customcollected

Quellen und Nachweise

ORD-Eintrag
ord-38a45616d9554c8cb9b640a4efefb8bd
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07491720B2

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