1H-indazol-7-amine → 5-Acetyl-2-ethyl-4-(1H-indazol-7-ylamino)-6-phenylpyridazin-3(2H)-one

HRID 1725540

Reaktionsgleichung

Reaktionsgleichung von HRID 1725540
[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[N+:19]([O-])=O)(=[O:3])[CH3:2].[NH:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][C:29]=2N)[CH:24]=[N:23]1>C(O)C>[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[NH:19][C:29]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:30]=1[NH:22][N:23]=[CH:24]2)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 889011H-indazol-7-amineHCID 107320155-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-one

Produkt 1

HCID 684883025-Acetyl-2-ethyl-4-(1H-indazol-7-ylamino)-6-phenylpyridazin-3(2H)-oneAusbeute 86,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 80 mg (0.278 mmol) of 5-acetyl-2-ethyl-4-nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al, J. Med. Chem. 1997, 40, 1417) in ethanol (4 mL), 1H-indazol-7-amine (56 mg, 0.417 mmol) was added. The resulting mixture was stirred at room temperature during one hour and the final product was collected by filtration and washed with diethylether to yield the title compound (90 mg, 86.5% yield).

Aufarbeitung

  1. filtrationthe final product was collected by filtration
  2. washwashed with diethylether

Quellen und Nachweise

ORD-Eintrag
ord-2f21093a501f4327b590125a11487d48
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07491722B2

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