3-Amino-5-methylisoxazole → 5-Acetyl-2-ethyl-4-[(5-methylisoxazol-3-yl)amino]-6-phenylpyridazin-3(2H)-one

HRID 1725542

Reaktionsgleichung

Reaktionsgleichung von HRID 1725542
[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[N+:19]([O-])=O)(=[O:3])[CH3:2].N[C:23]1[CH:27]=[C:26]([CH3:28])[O:25][N:24]=1>C(O)C>[C:1]([C:4]1[C:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[NH:19][C:23]1[CH:27]=[C:26]([CH3:28])[O:25][N:24]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 661723-Amino-5-methylisoxazoleHCID 107320155-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-one

Produkt 1

HCID 684884685-Acetyl-2-ethyl-4-[(5-methylisoxazol-3-yl)amino]-6-phenylpyridazin-3(2H)-oneAusbeute 37,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 80 mg (0.278 mmol) of 5-acetyl-2-ethyl nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al., J. Med. Chem. 1997, 40, 1417) in ethanol (4 mL), 3-amino-5-methylisoxazol (96 mg, 0.978 mmol) was added. The resulting mixture was stirred, at room temperature for four days and the final product was collected by filtration and washed with diethylether to yield the title compound (35 mg, 37.2% yield).

Aufarbeitung

  1. filtrationthe final product was collected by filtration
  2. washwashed with diethylether

Quellen und Nachweise

ORD-Eintrag
ord-ca5665ef37d84a5b8462c7b3679d20f7
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07491722B2

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