2-(3-Oxobutyl)isoindoline-1,3-dione → 3-{[[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-(1H-indol-5-yl)-amino]-methyl}-4-fluoro-benzonitrile

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-(3-Oxobutyl)isoindoline-1,3-dione	HCID 290728	—
Edukt	4-[(5-Cyano-2-fluoro-benzyl)-(1h-indol-5-yl)-amino]-piperidine-1-carboxylic acid tert-butyl ester	HCID 68972722	—
Produkt	3-{[[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-(1H-indol-5-yl)-amino]-methyl}-4-fluoro-benzonitrile	HCID 68970495	—

Reaktionsschritte

Using general procedure C with the above carbamate (400 mg, 0.891 mmol), then general procedure B with the resulting amine and 2-(3-oxo-butyl)-isoindole-1,3-dione (386 mg, 1.78 mmol) followed by general procedure D afforded 3-{[[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-(1H-indol-5-yl)-amino]-methyl}-4-fluoro-benzonitrile as a white solid (92 mg, 26% over 3 steps).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07491735B2
Quelldatensatz	uspto-grants-2009_02
ORD ID	ord-413c065e2e8f4bc196869ac20450809d
Quellennotiz	uspto-grants-2009_02