1-Boc-4-[Hydroxy-(4-trifluoromethoxyphenyl)methyl]piperidine → tert-Butyl 4-(4-(trifluoromethoxy)benzoyl)piperidine-1-carboxylate

HRID 1726241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1726241
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]([OH:26])[C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O>C(Cl)Cl>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:14](=[O:26])[C:15]2[CH:16]=[CH:17][C:18]([O:21][C:22]([F:23])([F:24])[F:25])=[CH:19][CH:20]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 120527841-Boc-4-[Hydroxy-(4-trifluoromethoxyphenyl)methyl]piperidineHCID 178418287HCID 178418287, Verbindung

Produkt 1

HCID 68968884tert-Butyl 4-(4-(trifluoromethoxy)benzoyl)piperidine-1-carboxylateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-[hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (see EXAMPLE 32) (604 mg, 1.61 mmol) in CH2Cl2 (8 mL) was added SiO2 (2 g) followed by PCC (1.04 g, 4.82 mmol), and the mixture was stirred at room temperature for 3 h to give 4-(4-trifluoromethoxy-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester as colourless crystals (601 mg, 100%) after purification.

Quellen und Nachweise

ORD-Eintrag
ord-aa4a1224a10c4668b12cbc71c6360b25
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07491735B2

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