Hydrochloric Acid → HCID 23154471, Verbindung

HRID 1726882Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1726882
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([S:22]([N:25]4[CH2:34][CH2:33][C:28]5(OCC[O:29]5)[CH2:27][CH2:26]4)(=[O:24])=[O:23])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[ClH:40]>>[ClH:40].[ClH:40].[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[N:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([S:22]([N:25]4[CH2:34][CH2:33][C:28](=[O:29])[CH2:27][CH2:26]4)(=[O:24])=[O:23])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 231544778-[[4-[6-[4-(1-Methylethyl)-1-piperazinyl]-3-pyridinyl]phenyl]sulfonyl]-1,4-dioxa-8-azaspiro[4.5]decane

Produkt 1

HCID 23154471HCID 23154471, Verbindung

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A suspension of 400 mg of the product obtained in Step C (0.82 mmol) in 5 ml of 1N HCl is stirred for 1 hour at 80° C. After neutralisation of the reaction mixture using 10% NaHCO3, the precipitate is filtered off, washed with water and dried. The white solid is suspended in ethanol and dissolved by adding methanolic HCl. The solution is evaporated to dryness and the residue is taken up in an ethanol/ethyl ether mixture to yield the expected product after filtration.

Aufarbeitung

  1. filtrationthe precipitate is filtered off
  2. washwashed with water
  3. customdried
  4. dissolutiondissolved
  5. additionby adding methanolic HCl
  6. customThe solution is evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-a666c67b36b64f4ea169e11abf46ad8a
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07494994B2

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