HCID 85844986, Verbindung → HCID 67211384, Verbindung

HRID 1727250Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1727250
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[NH:11][C:12]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[S:13]>[OH-].[Na+].[Fe-3](C#N)(C#N)(C#N)(C#N)(C#N)C#N.[K+].[K+].[K+]>[CH:14]1([C:12]2[S:13][C:5]3[C:6]([O:9][CH3:10])=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[C:4]=3[N:11]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Komponenten

4

Edukt 1

HCID 85844986HCID 85844986, Verbindung

Produkt 1

HCID 67211384HCID 67211384, VerbindungAusbeute 88,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178511488HCID 178511488, VerbindungKatalysatorHCID 14798Sodium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

1.26 g (4.50 mmol) of N-(2,5-dimethoxyphenyl)cyclohexanecarbothioamide is dissolved in 100 ml of a 1.5 M sodium hydroxide solution (100 ml) and the reaction medium is cooled down to 0° C. before adding 25 ml of a freshly prepared 20% aqueous solution of potassium ferricyanide (5.05 g of K3[Fe(CN)6]; 3.4 eq.). The reaction mixture is maintained under stirring at ambient temperature for 24 hours, then 1.1 g (yield=88%) of the expected benzothiazole derivative is obtained by filtration, washing with cold water and drying under reduced pressure in the presence of P2O5.

Aufarbeitung

  1. temperatureThe reaction mixture is maintained

Quellen und Nachweise

ORD-Eintrag
ord-8e467b1880694c60ab2b9bfc8d10eef9
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07495021B2

Notizen zur Reaktion

Wird geladen…