Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Pyrrolidine | HCID 31268 | — |
| Edukt | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Edukt | 5-Chloro-2-(3-hydroxy-propoxy)-benzaldehyde | HCID 57565935 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | HCID 86760828 | HCID 86760828 | 87,6% |
Reaktionsschritte
5-Chloro-2-(3-hydroxy-1-propoxy)-benzaldehyde (8 g, 37 mmol) and 6-chlorooxindole (6.2 g, 37 mmol) were mixed in anhydrous methanol (20 mL). Then pyrrolidine (3 mL, 37 mmol) was added slowly at r.t. The mixture was heated to 70° C. for 3 h and cooled to room temperature. The precipitate was collected by filtration to give title compound as a yellow solid (Yield: 11.8 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07495007B2 |
|---|
| Quelldatensatz | uspto-grants-2009_02 |
|---|
| ORD ID | ord-438e668c95e447499ba8cdc223373e7b |
|---|
| Quellennotiz | uspto-grants-2009_02 |
|---|
