1-Fluoro-2-methoxy-5-methyl-3-nitrobenzene → 3-Fluoro-2-methoxy-5-methylaniline

HRID 17286

Reaktionsgleichung

Reaktionsgleichung von HRID 17286
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[O:12][CH3:13]>[C].[Pd].CO>[F:1][C:2]1[C:3]([O:12][CH3:13])=[C:4]([CH:5]=[C:6]([CH3:8])[CH:7]=1)[NH2:9]

Komponenten

4

Edukt 1

HCID 575758761-Fluoro-2-methoxy-5-methyl-3-nitrobenzene

Produkt 1

HCID 451220523-Fluoro-2-methoxy-5-methylanilineAusbeute 81,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

5% Palladium-carbon (wet, 100 mg) was added to a methanol (5 ml) solution of 1-fluoro-2-methoxy-5-methyl-3-nitrobenzene (I-25) (250 mg, 1.35 mmol), followed by stirring under hydrogen atmosphere for 30 minutes. After filtration and concentration under reduced pressure, the resulting residue was subjected to column chromatography, and the eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure to obtain the entitled compound (170 mg, 81%) as a yellow oily substance.

Aufarbeitung

  1. filtrationAfter filtration and concentration under reduced pressure
  2. concentrationthe eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-51c75521558b47e6890a4a69c8e9f48b
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737166B2

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