Hydrochloric Acid → 5-Amino-2-propylimidazo[4,5-b]pyridine

HRID 1729411Notizen

Reaktionsgleichung

C([NH:6][C:7]1[N:12]=[C:11]2[N:13]=[C:14]([CH2:16][CH2:17][CH3:18])[NH:15][C:10]2=[CH:9][CH:8]=1)(=O)CCC.Cl>CO>[NH2:6][C:7]1[N:12]=[C:11]2[N:13]=[C:14]([CH2:16][CH2:17][CH3:18])[NH:15][C:10]2=[CH:9][CH:8]=1

Komponenten

Reaktionsbedingungen

Temperatur: 45 °C

Versuchsvorschrift

A mixture of 5-butyramido-2-propylimidazo[4,5-b]pyridine (250 mg, 1.07 mmol), MeOH (20 mL), and concentrated aqueous HCl (2 mL) was heated to 45° C. for 16 hours. Concentration and neutralization with NaHCO3 gave 150 mg of the title compound as a glass. 1H NMR (300 MHz, CD3OD) δ 7.57 (d, 1H, J=8.5 Hz), 6.46 (d, 1H, J=8.5 Hz), 2.76 (t, 2H, J=7.5 Hz), 1.85-1.70 (m, 2H), 0.93 (t, 3H, J=7.5 Hz).

Aufarbeitung

concentrationConcentration and neutralization with NaHCO3

Quellen und Nachweise

ORD-Eintrag: ord-b4c3b72856854060a5c8bd529adb50ad
Quelldatensatz: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05332744

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