Sodium Hydroxide → HCID 21401588, Verbindung

HRID 1730125Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1730125
[OH:1][CH:2]([CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8].C(OC(COC1C=CC(F)=CC=1)CCCN(CC#CCCCC(OC)=O)S(C)(=O)=O)(=O)C.[OH-].[Na+]>>[OH:1][CH:2]([CH2:22][O:23][C:24]1[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=1)[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][C:12]#[C:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8]

Komponenten

4

Edukt 3

HCID 14798Sodium HydroxideHCID 21401586Ethyl 7-{N-[4-hydroxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido}heptanoateHCID 21401649HCID 21401649, Verbindung

Produkt 1

HCID 21401588HCID 21401588, Verbindung

Versuchsvorschrift

The synthesis of this compound is carried out as described in Example 1, Step E except that the ethyl 7-{N-[4-hydroxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido} -heptanoate is replaced by an equimolar amount of methyl 7-{N-[4-acetoxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido}-hept- 5-ynoate and the amount of sodium hydroxide is doubled. The product of this reaction is the subject compound.

Aufarbeitung

  1. customThe synthesis of this compound

Quellen und Nachweise

ORD-Eintrag
ord-bdfb3d3442144665beeae132fe157b0e
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03991106

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