Cyclohexylamine → N-Cyclohexylacetoacetamide

HRID 1730616

Reaktionsgleichung

Reaktionsgleichung von HRID 1730616
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[CH:7]1([NH2:13])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1>C1C=CC=CC=1>[CH:7]1([NH:13][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1

Komponenten

4

Edukt 2

HCID 7965CyclohexylamineHCID 12661Diketene

Produkt 1

HCID 70805N-Cyclohexylacetoacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel2×

Versuchsvorschrift

A solution of diketene (42 g.) in benzene (74 ml.) is added dropwise with vigorous stirring to a solution of cyclohexylamine (49.6 g.) in benzene (125 ml.). The rate of addition is adjusted so that a gentle reflux is maintained. The benzene is removed under vacuum and the yellow oil crystallizes upon trituation with hexane. A yield of 88.7 g. of product melting at 66°-69° C. is obtained.

Aufarbeitung

  1. additionThe rate of addition
  2. temperaturea gentle reflux
  3. temperatureis maintained
  4. customThe benzene is removed under vacuum
  5. customthe yellow oil crystallizes upon trituation with hexane

Quellen und Nachweise

ORD-Eintrag
ord-f41e8808f013472d95e642b7057a0f3c
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03993637

Verknüpfte Notizen

Wird geladen…