Propanenitrile, 3-ethoxy- → 2-(3-Amino-2-pyrazolin-1-yl)pyridine
Reaktionsgleichung
[Na].[NH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)[NH2:3].C(O[CH2:13][CH2:14][C:15]#[N:16])C>C(O)C>[NH2:16][C:15]1[CH2:14][CH2:13][N:2]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=2)[N:3]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A 0.58 g. amount of sodium metal is dissolved in 150 ml. of absolute ethanol, then 14.0 g. of 2-hydrazinopyridine is added followed by 12.7 g. of betaethoxypropionitrile. The reaction mixture is refluxed on a steam bath for 16 hours, then the solvent is removed in vacuo. Water is added and the solid collected by filtration. The solid is recrystallized twice from acetone to give 5.55 g. of the product of the Example as tan colored crystals, m.p. 168.5°-171° C.
Aufarbeitung
- temperatureThe reaction mixture is refluxed on a steam bath for 16 hours
- customthe solvent is removed in vacuo
- additionWater is added
- filtrationthe solid collected by filtration
- customThe solid is recrystallized twice from acetone
- customto give 5.55 g
Quellen und Nachweise
- ORD-Eintrag
- ord-4e67e853bdf443e5ae26b09991027a76
- Quelldatensatz
- uspto-grants-1986_11
- Patentnummer
- US04622401
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