Choline → HCID 20228180, Verbindung

HRID 1731661

Reaktionsgleichung

Reaktionsgleichung von HRID 1731661
C(O[CH2:4][CH2:5][C:6]#[N:7])C.C(O)C.[NH:11]([C:13]1[S:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1)[NH2:12].OCC[N+](C)(C)C>CO>[NH2:7][C:6]1[CH2:5][CH2:4][N:11]([C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[N:12]=1

Komponenten

6

Edukt 4

HCID 305CholineHCID 702EthanolHCID 119882-Benzothiazolinone, hydrazoneHCID 16501Propanenitrile, 3-ethoxy-

Produkt 1

HCID 20228180HCID 20228180, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 5.0 g. of β-ethoxypropionitrile, 100 ml. of absolute ethanol, 8.25 g. of 2-hydrazinobenzothiazole and 2.5 g. of 50% w/v choline in methanol is refluxed on a steam bath for 16 hours, then the solvent is removed in vacuo. Water is added and the solid is collected by filtration. The solid is recrystalized twice from ethanol to give 5.75 g. of the product of the Example as grey prisms, m.p. 231.5°-235° C.

Aufarbeitung

  1. additionA mixture of 5.0 g
  2. temperatureis refluxed on a steam bath for 16 hours
  3. customthe solvent is removed in vacuo
  4. additionWater is added
  5. filtrationthe solid is collected by filtration
  6. customThe solid is recrystalized twice from ethanol
  7. customto give 5.75 g

Quellen und Nachweise

ORD-Eintrag
ord-96eb4ec0f63c4844ba66b37c8d009237
Quelldatensatz
uspto-grants-1986_11
Patentnummer
US04622401

Verknüpfte Notizen

Wird geladen…