Thionyl Chloride → 3,4,5-Trihydroxybenzonitrile

Temperatur

90 °C

A reaction mixture containing 23.5 g. of gallamide, 180 ml. of ethyl acetate and 35 ml. of thionylchloride was refluxed for about 18 hours. The volatile contents were removed by evaporation in vacuo and the resulting residue dissolved in 215 ml. of water. This aqueous solution was heated to about 90° C. until the evolution of gas had ceased. The aqueous solution was filtered through charcoal and the water removed from the filtrate by evaporation. 18 g. of gallonitrile were obtained melting at about 219° C. with decomposition (86% yield). Other nitriles useful as starting materials can be prepared similarly.

1. additionA reaction mixture containing 23.5 g
2. customThe volatile contents were removed by evaporation in vacuo
3. dissolutionthe resulting residue dissolved in 215 ml
4. filtrationThe aqueous solution was filtered through charcoal
5. customthe water removed from the filtrate by evaporation

ORD-Eintrag

ord-35d974ef12da44cf8d8830ca5f50aa58

Quelldatensatz

uspto-grants-1986_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04623659