Dimethylamine → 1-ethyl-N,N-dimethyl[1,2,4]triazolo[4,3-a]quinoxalin-4-amine

HRID 1731940Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1731940
Cl[C:2]1[C:3]2[N:4]([C:12]([CH2:15][CH3:16])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:17][NH:18][CH3:19]>CN(C)C=O>[CH3:17][N:18]([CH3:19])[C:2]1[C:3]2[N:4]([C:12]([CH2:15][CH3:16])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 133857064-Chloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline

Produkt 1

HCID 8992951-ethyl-N,N-dimethyl[1,2,4]triazolo[4,3-a]quinoxalin-4-amineAusbeute 42 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-Chloro-1-ethyl-[1,2,4]triazolo-[4,3-a]quinoxaline (1.2 g., 0.005 mole), the product of Example 4, and 676 mg. (0.015 mole) of anhydrous dimethylamine in N,N-dimethylformamide (50 ml.) were stirred at 0° C. for 30 minutes and at room temperature for 2 hours. The reaction mixture was poured over ice and stirred for 20 minutes. The precipitate which formed was separated by filtration, washed with water and air dried. Recrystallization from chloroform and then from chloroform/cyclohexane afforded 510 mg. (42% yield) of 4-dimethylamino-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 155°-8° C.

Aufarbeitung

  1. additionThe reaction mixture was poured over ice
  2. customThe precipitate which formed
  3. customwas separated by filtration
  4. washwashed with water and air
  5. customdried
  6. customRecrystallization from chloroform
  7. customfrom chloroform/cyclohexane afforded 510 mg

Quellen und Nachweise

ORD-Eintrag
ord-f438f51f835b4a998c6c758a71ce919f
Quelldatensatz
uspto-grants-1986_11
Patentnummer
US04623725

Notizen zur Reaktion

Wird geladen…