Ethyl orthopropionate → 4,8-Dichloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline

HRID 1731947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1731947
[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:14])[CH:8]=2)[N:3]=1.[C:15](OCC)(OCC)(OCC)[CH2:16][CH3:17]>>[Cl:1][C:2]1[C:11]2[N:10]([C:15]([CH2:16][CH3:17])=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][CH:6]=[C:7]([Cl:14])[CH:8]=2

Komponenten

3

Edukt 2

HCID 66995Ethyl orthopropionateHCID 14733462,6-Dichloro-3-hydrazinylquinoxaline

Produkt 1

HCID 133857214,8-Dichloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxalineAusbeute 62 %

Versuchsvorschrift

2,6-Dichloro-3-hydrazinoquinoxaline (1.0 g., 0.0044 mole), the product of Preparation L(a), was refluxed with 15 ml. of triethyl orthopropionate for 4 hours and cooled to room temperature. The precipitate was recovered by filtration, washed with cyclohexane and air dried to afford 730 mg. (62% yield) of 4,8-dichloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. >250° C.

Aufarbeitung

  1. temperaturewas refluxed with 15 ml
  2. filtrationThe precipitate was recovered by filtration
  3. washwashed with cyclohexane and air
  4. customdried
  5. customto afford 730 mg

Quellen und Nachweise

ORD-Eintrag
ord-a0d76c46a12b454ab4e84a1cb523fb9d
Quelldatensatz
uspto-grants-1986_11
Patentnummer
US04623725

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