Benzene, (triethoxymethyl)- → 4-Chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline

HRID 1731953

Reaktionsgleichung

Reaktionsgleichung von HRID 1731953
[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.CCO[C:17](OCC)(OCC)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[Cl:1][C:2]1[C:11]2[N:10]([C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2

Komponenten

4

Edukt 2

HCID 74268Benzene, (triethoxymethyl)-HCID 36588202-Chloro-3-hydrazinoquinoxaline

Produkt 1

HCID 8992904-Chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2-Chloro-3-hydrazinoquinoxaline (2.2 g., 0.011 mole) was mixed with 6 ml. of triethyl orthobenzoate and heated at 100° C. for 30 minutes. After cooling the orange mixture to room temperature, ethanol was added. Filtration of the resultant precipitate afforded 2.1 g. of crude product which was further purified by means of trituration with warm methanol, followed by filtration and air drying to ultimately yield 1.58 g. (51%) of pure 4-chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline as an orange solid.

Aufarbeitung

  1. filtrationFiltration of the resultant precipitate
  2. customafforded 2.1 g
  3. customof crude product which was further purified by means of trituration with warm methanol
  4. filtrationfollowed by filtration and air
  5. customdrying to ultimately yield 1.58 g

Quellen und Nachweise

ORD-Eintrag
ord-4f1d2c03844946daacc2ec1c0ef5cc54
Quelldatensatz
uspto-grants-1986_11
Patentnummer
US04623725

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