Phosphorus oxychloride → 2-Chloro-6-fluoroquinoline

HRID 1732187Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1732187
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=O)[CH:6]=[CH:5]2.P(Cl)(Cl)([Cl:15])=O>>[Cl:15][C:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=2)[N:8]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 98340436-Fluoro-1,2-dihydroquinolin-2-one

Produkt 1

HCID 150594332-Chloro-6-fluoroquinoline

Versuchsvorschrift

A mixture of the so-prepared 6-fluorocarbostyril (2.9 gm, 0.018 mole) and 30.0 ml of phosphorous oxychloride was refluxed for 1.5 hr. Most of the excess phosphorous oxychloride was then distilled off under aspirator vacuum and the residue poured over crushed ice. The reaction mixture was made nearly neutral with 50% sodium hydroxide. The crude solid product was collected by filtration, taken up in

Aufarbeitung

  1. temperaturewas refluxed for 1.5 hr
  2. distillationMost of the excess phosphorous oxychloride was then distilled off under aspirator vacuum
  3. additionthe residue poured
  4. customover crushed ice
  5. filtrationThe crude solid product was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-0793f36da021490f8ff5dd1a0618968b
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04236912

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