Ethyl phenylacetate → HCID 3599665, Verbindung

HRID 1732647Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1732647
[Na].[C:2]1([C:8](=[N:17][NH2:18])[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=O)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]1([CH2:25][C:26](OCC)=[O:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[C:19]1([C:25]2[C:26](=[O:27])[NH:18][N:17]=[C:8]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:9]=2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

5

Edukt 3

HCID 7590Ethyl phenylacetateHCID 792892-Hydrazinylidene-1,2-diphenylethanoneHCID 5360545Sodium

Produkt 1

HCID 3599665HCID 3599665, VerbindungAusbeute 30 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Sodium (11.5 g) was allowed to react with ethanol and then benzilmonohydrazone (120 g) and ethyl phenylacetate (84 g) were added and the reaction mixture heated at reflux for 3 hours. The reaction was quenched in water and the suspension acidified. The resulting precipitate was separated and refluxed with acetonitrile, cooled and separated by filtration to obtain 4,5,6-triphenyl-2H-pyridazin-3-one (30 percent yield), m.p. 290°-292° C.

Aufarbeitung

  1. temperaturethe reaction mixture heated
  2. temperatureat reflux for 3 hours
  3. customThe reaction was quenched in water
  4. customThe resulting precipitate was separated
  5. temperaturerefluxed with acetonitrile
  6. temperaturecooled
  7. customseparated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-55950ba73e8b432b8932beb92676e01b
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04238490

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