Lithium hydride → HCID 178522542, Verbindung

HRID 1732888Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1732888
I.[NH:2]=[C:3]1[NH:7][CH2:6][CH2:5][NH:4]1.[H-].[Li+].[Br:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Br:17])[C:12]=1[N:18]=[C:19]=[O:20]>CN(C)C=O>[Br:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Br:17])[C:12]=1[NH:18][C:19]([N:2]=[C:3]1[NH:7][CH2:6][CH2:5][NH:4]1)=[O:20]

Komponenten

5

Edukt 3

HCID 62714Lithium hydrideHCID 202306671,3-Dibromo-2-isocyanatobenzeneHCID 178506595HCID 178506595, Verbindung

Produkt 1

HCID 178522542HCID 178522542, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel3×

Versuchsvorschrift

In a manner similar to that described in Examples II and III, a solution of 12.0 grams (0.0563 mole) of 2-iminoimidazolidine hydroiodide in 50 milliliters of dry dimethylformamide is added dropwise with cooling and under an atmosphere of nitrogen to a suspension of 447 milligrams (0.0563 mole) of lithium hydride in 50 milliliters of dry dimethylformamide. After completion of the addition the mixture is allowed to warm to room temperature over a period of about half an hour, then cooled to 0°-5° C., and a solution of 7.8 grams (0.0282 mole) of 2,6-dibromophenyl isocyanate in 25 milliliters of dry dimethylformamide is added dropwise over a two hour period while maintaining the cooled temperature range. The mixture is then allowed to warm to room temperature and stirred overnight under nitrogen to obtain the desired N-(2,6-dibromophenyl)-N'-(2-imidazolidinylidene)urea product in the reaction mixture. The product is recovered from the reaction mixture by pouring the mixture into 400 milliliters of ice water, acidifying with 10 percent hydrochloric acid to pH below 3, filtering to remove impurities, saturating the filtrate with solid sodium chloride and basifying with potassium carbonate to a pH of 8-9 to precipate the N-(2,6-dibromophenyl)-N'-(2-imidazolidinylidene)urea product as a white solid, m.p. 185°-190° C. (dec.)

Aufarbeitung

  1. additionAfter completion of the addition the mixture
  2. temperaturecooled to 0°-5° C.
  3. temperaturewhile maintaining the cooled temperature range
  4. temperatureto warm to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-c695718f64c7448390b933a9d357e33f
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04239768

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