Dimethylamine → HCID 20300366, Verbindung

HRID 1733142Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1733142
[C:1]([C:3]1[C:7]([C:8]([CH3:11])([CH3:10])[CH3:9])=[CH:6][S:5][C:4]=1[N:12]=[C:13]=[O:14])#[N:2].[CH3:15][NH:16][CH3:17]>C1(C)C=CC=CC=1>[C:1]([C:3]1[C:7]([C:8]([CH3:10])([CH3:11])[CH3:9])=[CH:6][S:5][C:4]=1[NH:12][C:13]([N:16]([CH3:17])[CH3:15])=[O:14])#[N:2]

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 13742718HCID 13742718, Verbindung

Produkt 1

HCID 20300366HCID 20300366, VerbindungAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

20.6 g (0.1 mole) of 3-cyano-4-tert.-butyl-thien-2-yl isocyanate were added dropwise to a solution of 6.5 g (0.145 mole) of dimethylamine in 200 ml of toluene at room temperature. After the exothermic reaction had subsided, the mixture was concentrated and the residue was recrystallized from a little toluene. 20.1 g of 1-(3-cyano-4-tert.-butyl-thien-2-yl)-3,3-dimethyl-urea of melting point 140° C. were obtained in this manner.

Aufarbeitung

  1. customAfter the exothermic reaction
  2. concentrationthe mixture was concentrated
  3. customthe residue was recrystallized from a little toluene

Quellen und Nachweise

ORD-Eintrag
ord-90b0459364334427863ee1003e5f9b52
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04240820

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