Acetyl chloride → HCID 20300372, Verbindung

HRID 1733145Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1733145
C(N(CC)CC)C.[NH2:8][C:9]1[S:10][CH:11]=[C:12]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:13]=1[C:14]([NH2:16])=[O:15].[C:21](Cl)(=[O:23])[CH3:22]>C1(C)C=CC=CC=1>[C:21]([NH:8][C:9]1[S:10][CH:11]=[C:12]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:13]=1[C:14]([NH2:16])=[O:15])(=[O:23])[CH3:22]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 16793423HCID 16793423, Verbindung

Produkt 1

HCID 20300372HCID 20300372, VerbindungAusbeute 80,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

21.2 g (0.21 mole) of triethylamine were first added to a suspension of 39.6 g (0.2 mole) of 2-amino-3-aminocarbonyl-4-tert.-butyl-thiophene in 300 ml of toluene, and 16.5 g (0.21 mole) of acetyl chloride were then added dropwise. After the exothermic reaction had ended, the mixture was worked up by filtering off the solid product and washing it with water. 38.6 g of 2-acetylamino-3-aminocarbonyl-4-tert.-butyl-thiophene of melting point 251° C. were obtained in this manner.

Aufarbeitung

  1. additionwere then added dropwise
  2. customAfter the exothermic reaction
  3. filtrationby filtering off the solid product
  4. washwashing it with water

Quellen und Nachweise

ORD-Eintrag
ord-5f46feac3e124eb28d3a233b453c7af9
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04240820

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