Hydrochloric Acid → 2-Chloro-N-(3-cyano-4,5-dimethyl-2-furanyl)acetamide

HRID 1733147

Reaktionsgleichung

Reaktionsgleichung von HRID 1733147
[NH2:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([CH3:9])[C:6]=1[C:7]#[N:8].[Cl:11][CH2:12][C:13](Cl)=[O:14].Cl>C1(C)C=CC=CC=1>[Cl:11][CH2:12][C:13]([NH:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([CH3:9])[C:6]=1[C:7]#[N:8])=[O:14]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 2902202-Amino-4,5-dimethyl-3-furancarbonitrile

Produkt 1

HCID 162273542-Chloro-N-(3-cyano-4,5-dimethyl-2-furanyl)acetamideAusbeute 122,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

20.4 g (0.1 mole) of 2-amino-3-cyano-4,5-dimethylfurane and 17.5 g (0.155 mole) of chloroacetyl chloride were boiled in 200 ml of toluene until the evolution of hydrogen chloride had subsided. Thereafter, the solvent was evaporated off under reduced pressure and the residue was recrystallized from ethyl acetate. 26 g of 2-chloroacetylamino-3-cyano-4,5-dimethylfurane of melting point 114° C. were obtained in this manner.

Aufarbeitung

  1. customThereafter, the solvent was evaporated off under reduced pressure
  2. customthe residue was recrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-732f528106744e908873ac48e9d38c0e
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04240820

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