Thionyl Chloride → 2-Bromo-3,3,3-trifluoropropanoyl chloride

Reaktionsgleichung

[Br:1][CH:2]([C:6]([F:9])([F:8])[F:7])[C:3](O)=[O:4].S(Cl)([Cl:12])=O>>[Br:1][CH:2]([C:6]([F:9])([F:8])[F:7])[C:3]([Cl:12])=[O:4]

Komponenten

Edukt 2

HCID 24386Thionyl Chloride

HCID 136803062-Bromo-3,3,3-trifluoropropanoic acid

Produkt 1

HCID 540458592-Bromo-3,3,3-trifluoropropanoyl chloride

Versuchsvorschrift

A solution of 2-bromo-3,3,3-trifluoropropanoic acid (5 g.) in thionyl chloride (5 ml.) is refluxed in the steam bath for two hours. The excess thionyl chloride is removed in vacuo, and the residue distilled under reduced pressure to yield 2-bromo-3,3,3-trifluoropropanoic acid chloride.

Aufarbeitung

customThe excess thionyl chloride is removed in vacuo
distillationthe residue distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag: ord-17e0cc6d16604f04b024430f25787f22
Quelldatensatz: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04241076

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