Potassium Hydroxide → 2-Isoxazolidinecarboxylic acid, ethyl ester
Reaktionsgleichung
C(Br)CCBr.[C:6]([N:11]1[CH2:15][CH2:14][CH2:13][O:12]1)([O:8][CH2:9][CH3:10])=[O:7].[OH-].[K+]>>[C:6]([N:11]1[CH2:15][CH2:14][CH2:13][O:12]1)([O:8][CH2:9][CH3:10])=[O:7]Komponenten
3
Versuchsvorschrift
N-Carbethoxyisooxazolidine Trimethylene dibromide (40.4 g; 0.4 mole) and an ethanolic solution (224 ml.) containing potassium hydroxide (22.4 g.; 0.4 mole) are boiled together on a steam bath for six hours. The ethanol is removed by distillation and the residue triturated with ether (3×100 ml.). The combined ether washes are dried over anhydrous magnesium sulfate, filtered and concentrated to give a liquid which is vacuum distilled to give N-carbethoxyisooxazolidine, b.p. 103° C./13 mm.
Aufarbeitung
- customThe ethanol is removed by distillation
- customthe residue triturated with ether (3×100 ml.)
- dry with materialThe combined ether washes are dried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated
- customto give a liquid which
- distillationdistilled
Quellen und Nachweise
- ORD-Eintrag
- ord-86d8d24da0ef42e8bce93d446dc10c72
- Quelldatensatz
- uspto-grants-1980_12
- Patentnummer
- US04242339
Notizen zur Reaktion
Wird geladen…