Acetone → N-[4-(hexadecylamino)benzoyl]urea

HRID 1733513

Reaktionsgleichung

Reaktionsgleichung von HRID 1733513
Cl.[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[NH2:28][C:29]([NH2:31])=[O:30].[Na].CC(C)=O>C(Cl)Cl>[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:28][C:29]([NH2:31])=[O:30])=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Komponenten

5

Edukt 3

HCID 180AcetoneHCID 132553224-Hexadecylaminobenzoyl chloride hydrochlorideHCID 86736265Urea, monosodium salt

Produkt 1

HCID 20437348N-[4-(hexadecylamino)benzoyl]urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The 12.6 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride in methylene chloride is added to 5 g. of sodium urea in 30 ml. of acetone and the mixture is stirred at 20° C. for 18 hours. Dilute alkali is added and the solid washed with alkaline aqueous acetone. Recrystallization from ethanol gives pure white crystals of product.

Aufarbeitung

  1. additionDilute
  2. additionalkali is added
  3. washthe solid washed with alkaline aqueous acetone
  4. customRecrystallization from ethanol
  5. customgives pure white crystals of product

Quellen und Nachweise

ORD-Eintrag
ord-7545ce9dbbde445098de3e86452bb47c
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04242273

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