Timonacic → 3-[4-(Hexadecylamino)benzoyl]-4-carboxythiazolidine

HRID 1733515

Reaktionsgleichung

Reaktionsgleichung von HRID 1733515
[CH2:1]([NH:17][C:18]1[CH:35]=[CH:34][C:21]([C:22]([N:24]2[CH:28]([C:29]([O:31]CC)=[O:30])[CH2:27][S:26][CH2:25]2)=[O:23])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].S1CC(C(O)=O)NC1>C(=O)(O)[O-].[Na+].CC(C)=O>[CH2:1]([NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([N:24]2[CH:28]([C:29]([OH:31])=[O:30])[CH2:27][S:26][CH2:25]2)=[O:23])=[CH:34][CH:35]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Komponenten

4

Edukt 2

HCID 9934TimonacicHCID 204373423-[4-(Hexadecylamino)benzoyl]-4-carboethoxythiazolidine

Produkt 1

HCID 204373653-[4-(Hexadecylamino)benzoyl]-4-carboxythiazolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 86737261Acetone sodium bicarbonateLösungsmittel

Versuchsvorschrift

By means of the alkaline hydrolysis method of Example 7, the ethyl ester of Example 21 is converted to the subject carboxylic acid. This acid is also prepared using the procedure of Example 21 except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.

Aufarbeitung

  1. customBy means of the alkaline hydrolysis method of Example 7
  2. customThis acid is also prepared

Quellen und Nachweise

ORD-Eintrag
ord-346a798835094e4b8ffafaca0534f146
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04242273

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