Hydrochloric Acid → 1-[3-(aminomethyl)phenyl]ethan-1-one hydrochloride
Reaktionsgleichung
[CH3:1][C:2]1([C:7]2[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=2)[CH2:10][NH2:11])OCC[O:3]1.[ClH:15]>CO>[ClH:15].[C:2]([C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[CH2:10][NH2:11])(=[O:3])[CH3:1]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 3-(2-methyl-1,3-dioxolan-2-yl)benzylamine (57.2 g) in 1N hydrochloric acid (500 ml) and methanol (500 ml) was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure. The residue was dissolved in methanol. The resulting precipitate was removed by filtration. The solvent was removed under reduced pressure. Recrystallization from a mixture of ethanol and acetone afforded 3-acetylbenzylamine hydrochloride (31.2 g).
Aufarbeitung
- customThe solvent was removed under reduced pressure
- dissolutionThe residue was dissolved in methanol
- customThe resulting precipitate was removed by filtration
- customThe solvent was removed under reduced pressure
- customRecrystallization
- additionfrom a mixture of ethanol and acetone
Quellen und Nachweise
- ORD-Eintrag
- ord-205cfc1d3f0f472e8b6e80b5f4dff919
- Quelldatensatz
- uspto-grants-1996_07
- Patentnummer
- US05532258
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