Trifluoromethyluracil → 5-Trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine

HRID 1734119Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1734119
[F:1][C:2]([F:12])([F:11])[C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1.[CH3:13][Si:14]([CH3:17])([CH3:16])Cl>C[Si](C)(C)N[Si](C)(C)C>[F:12][C:2]([F:11])([F:1])[C:3]1[C:4]([O:10][Si:14]([CH3:17])([CH3:16])[CH3:13])=[N:5][C:6]([O:9][Si:14]([CH3:17])([CH3:16])[CH3:13])=[N:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 5899TrifluoromethyluracilHCID 6397Chlorotrimethylsilane

Produkt 1

HCID 109909625-Trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13838HexamethyldisilazaneLösungsmittel

Versuchsvorschrift

In 50 ml of hexamethyldisilazane, 6.16 g of 5-trifluoromethyluracil was suspended and then 0.22 ml of trimethylchlorosilane was added to the suspension, followed by heating the resulting mixture to reflux for 5 hours. After the reaction, the excess hexamethyldisilazane was removed by evaporation and the resultant was distilled in vacuum. All of the fractions of distillate obtained at about 60° C. under 1 mmHg were collected. Yield: 10.3 g

Aufarbeitung

  1. temperatureby heating the resulting mixture
  2. temperatureto reflux for 5 hours
  3. customAfter the reaction
  4. customthe excess hexamethyldisilazane was removed by evaporation
  5. distillationthe resultant was distilled in vacuum
  6. customAll of the fractions of distillate obtained at about 60° C. under 1 mmHg
  7. customwere collected

Quellen und Nachweise

ORD-Eintrag
ord-584c1ea662e0478e8b7213f4c54bf5ae
Quelldatensatz
uspto-grants-1996_07
Patentnummer
US05532349

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