Hydrochloric Acid → 2-Methoxy-4-methylpyridin-3-amine

HRID 1734121Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1734121
C(OC([NH:8][C:9]1[C:10]([O:16][CH3:17])=[N:11][CH:12]=[CH:13][C:14]=1[CH3:15])=O)(C)(C)C.Cl>CCOC(C)=O>[NH2:8][C:9]1[C:10]([O:16][CH3:17])=[N:11][CH:12]=[CH:13][C:14]=1[CH3:15]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 10082908Tert-butyl 2-methoxy-4-methylpyridin-3-ylcarbamate

Produkt 1

HCID 103293612-Methoxy-4-methylpyridin-3-amineAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3-(tert-Butoxycarbonylamino)-2-methoxy-4-methylpyridine (0.7 g, 2.9 mmol) was treated with 25 mL of 4M HCl in EtOAc at room temperature overnight. The resulting suspension was carefully washed with sat. NaHCO3, dried (MgSO4) and concentrated to give 0.4 g of the free amine as an oil (100%). m.p. (HCl salt): 199° C. (d).

Aufarbeitung

  1. washThe resulting suspension was carefully washed with sat. NaHCO3
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9ff4367edf7e4ff59a9646f0405f517f
Quelldatensatz
uspto-grants-1996_07
Patentnummer
US05532358

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