Pyrrolidine → 5-Benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

HRID 1734252

Reaktionsgleichung

Reaktionsgleichung von HRID 1734252
[CH2:1]([O:8][C:9]1[C:10](=[O:17])[CH2:11][C:12]([CH:15]=[CH2:16])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>O1CCCC1.C(OC(C)C)(C)C>[CH2:1]([O:8][C:9]1[C:10](=[O:17])[CH2:11][C:12]([CH2:15][CH2:16][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 31268PyrrolidineHCID 677480895-Benzyloxy-2-vinyl-4-pyridone

Produkt 1

HCID 677480915-Benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 7914Diisopropyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]-4-pyridone (3.79 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperaturerefluxed for an hour
  3. temperatureThe mixture was cooled
  4. filtrationthe resulting precipitate was collected by filtration
  5. washwashed with diisopropyl ether
  6. customair-dried at ambient temperature

Quellen und Nachweise

ORD-Eintrag
ord-7dd94348d6ef4806be9e10a7289f9faa
Quelldatensatz
uspto-grants-1996_07
Patentnummer
US05532354

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