Ethylenediamine → HCID 21472721, Verbindung

HRID 1736473Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1736473
[C:1]([O:5][C:6]([N:8]1[C:12]2[C:13]([F:21])=[CH:14][C:15]([N:18]=[C:19]=[S:20])=[C:16]([CH3:17])[C:11]=2[N:10]=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:22]([NH2:25])[CH2:23][NH2:24]>C(Cl)Cl>[C:1]([O:5][C:6]([N:8]1[C:12]2[C:13]([F:21])=[CH:14][C:15]([NH:18][C:19]([NH:24][CH2:23][CH2:22][NH2:25])=[S:20])=[C:16]([CH3:17])[C:11]=2[N:10]=[CH:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 3301EthylenediamineHCID 21472729HCID 21472729, Verbindung

Produkt 1

HCID 21472721HCID 21472721, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of 1-tert-butoxycarbonyl-7-fluoro-4-methyl-5-benzimidazolylisothiocyanate (0.42 g) in methylene chloride (50 mL) is added dropwise over 15 minutes to 1,2-ethylenediamine (0.45 mL) in solution in methylene chloride (100 mL). The mixture is stirred for 10 minutes at room temperature, then rotary evaporated. The residue is triturated for 30 minutes with ether (100 mL). The resulting white suspension is filtered and the solid is dried in vacuo overnight.

Aufarbeitung

  1. customThe residue is triturated for 30 minutes with ether (100 mL)
  2. filtrationThe resulting white suspension is filtered
  3. customthe solid is dried in vacuo overnight

Quellen und Nachweise

ORD-Eintrag
ord-3e316eac530f430196c7f84b17d9600a
Quelldatensatz
uspto-grants-1996_07
Patentnummer
US05541210

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