Pivaloyl chloride → HCID 22611644, Verbindung
Reaktionsgleichung
C([O-])C.Cl.Cl.[NH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[C:10]2[CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1.[CH3:23][C:24]([CH3:29])([CH3:28])[C:25](Cl)=[O:26]>>[CH3:23][C:24]([CH3:29])([CH3:28])[C:25]([NH:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[C:10]2[CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)=[O:26]Komponenten
3
Versuchsvorschrift
Beginning with 2.00 gm (5.74 mMol) 5-amino-3-(1-methyl-piperidin-4-yl)-1H-indole dihydrochloride ethanolate and 1.78 gm (14.4 mMol) trimethylacetyl chloride, 0.623 gm (34.6%) of the title compound were recovered as an off-white powder.
Quellen und Nachweise
- ORD-Eintrag
- ord-91874ff711e04dca8926ccbdaaf0ba0b
- Quelldatensatz
- uspto-grants-1999_10
- Patentnummer
- US05962474