HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(4-Fluorophenyl)-2-propenoic acid → 1-[1-(4-Cyanophenyl)-4-(4-fluorophenyl)-2-oxobutyl]-1,2,4-triazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(4-Fluorophenyl)-2-propenoic acid | HCID 98070 | — |
| Edukt | 4-(1,2,4-Triazol-1-ylmethyl)benzonitrile | HCID 7537616 | — |
| Edukt | Benzenepropanoic acid, 4-fluoro-, ethyl ester | HCID 11816416 | — |
| Edukt | Butyllithium | HCID 178418339 | — |
| Produkt | 1-[1-(4-Cyanophenyl)-4-(4-fluorophenyl)-2-oxobutyl]-1,2,4-triazole | HCID 21843580 | — |
Reaktionsschritte
1-[1-(4-cyanophenyl)-4-(4-fluorophenyl)-2-oxobutyl]-1,2,4-triazole is prepared according to the procedure described in Example 1 starting from 1-(4-cyanobenzyl)-1,2,4-triazole (1.7 g, 0.0092 mol), n-BuLi (0.0108 mol) and ethyl 3-(4-fluorophenyl)propionate (2.3 g, 0.0117 mol) prepared from 4-fluorocinnamic acid by esterification and hydrogenation. The product is purified by flash chromatography methylene chloride-methanol (95:5) as eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05962495 |
| Quelldatensatz | uspto-grants-1999_10 |
| ORD ID | ord-5bdc9d226d0f4139b19173e36e35b09e |
| Quellennotiz | uspto-grants-1999_10 |