Ethyl isocyanate → HCID 22611366, Verbindung

HRID 1737980Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1737980
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH2:18]([N:20]=[C:21]=[O:22])[CH3:19]>C(Cl)(Cl)Cl>[CH2:18]([NH:20][C:21]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:22])[CH3:19]

Komponenten

4

Edukt 2

HCID 8022Ethyl isocyanateHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Produkt 1

HCID 22611366HCID 22611366, VerbindungAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 15.0 mg (0.0655 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole in 3.0 mL chloroform were added 9.3 mg (0.131 mMol) ethyl isocyanate. The reaction was mixed for 48 hours and to it were then added 0.23 gm (0.131 mMol) aminomethylated polystyrene and the reaction mixed for an additional 18 hours. The reaction mixture was then filtered and the volatiles evaporated to give 16.1 mg (82%) of the title compound.

Aufarbeitung

  1. additionThe reaction was mixed for 48 hours and to it
  2. additionwere then added 0.23 gm (0.131 mMol)
  3. additionthe reaction mixed for an additional 18 hours
  4. filtrationThe reaction mixture was then filtered
  5. customthe volatiles evaporated

Quellen und Nachweise

ORD-Eintrag
ord-af7ae28aaec945cc9c55c53612e908dc
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05962473

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