Methyl 3-nitro-4-(3-methoxy-phenoxy)-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-benzoate → HCID 23288716, Verbindung

HRID 1738640Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1738640
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:23][CH2:24][CH2:25][O:26][CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][O:28]2)[C:13]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=1)[C:7]([O:9][CH3:10])=[O:8])([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:23][CH2:24][CH2:25][O:26][CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][O:28]2)[C:13]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=1)[C:7]([O:9][CH3:10])=[O:8]

Komponenten

4

Edukt 1

HCID 23288605Methyl 3-nitro-4-(3-methoxy-phenoxy)-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-benzoate

Produkt 1

HCID 23288716HCID 23288716, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3.5 g of methyl 3-nitro-4-(3-methoxy-phenoxy)-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-benzoate were dissolved in methanol (100 ml), treated with 0.5 g of Ra--Ni catalyst and hydrogenated at room temperature for 1 hour. The catalyst was filtered off and the solution was concentrated on a rotary evaporator. There was thus obtained the desired methyl 3-amino-4-(3-methoxy-phenoxy)-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-benzoate as a pale yellow solid.

Aufarbeitung

  1. additiontreated with 0.5 g of Ra
  2. filtrationThe catalyst was filtered off
  3. concentrationthe solution was concentrated on a rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-2211a2b5c91545aa8fa3c078203958dc
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05962682

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