2-Fluoro-2-trifluoromethyl-4-decenamide → 2-Fluoro-2-trifluoromethyldecanamide

HRID 1738739Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1738739
[F:1][C:2]([C:14]([F:17])([F:16])[F:15])([CH2:6][CH:7]=[CH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:3]([NH2:5])=[O:4].[H][H]>CO.[C].[Pd]>[F:1][C:2]([C:14]([F:15])([F:17])[F:16])([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:3]([NH2:5])=[O:4]

Komponenten

5

Edukt 2

HCID 540171342-Fluoro-2-trifluoromethyl-4-decenamideHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 218389812-Fluoro-2-trifluoromethyldecanamideAusbeute 120,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Into a solution of 3.0 g (9.65 mmol) of 2-fluoro-2-trifluoromethyl-4-decenamide in 30 ml of methanol, palladium-carbon (75 mg) was added under nitrogen. After the atmosphere was replaced with hydrogen, the mixture was stirred for 24 hours. To remove the catalyst, the resulting mixture was filtered with celite and the filtrate was concentrated. The raw product was purified using silica gel column chromatography to obtain 3.0 g of the desired compound. The yield was 99.3%.

Aufarbeitung

  1. customTo remove the catalyst
  2. filtrationthe resulting mixture was filtered with celite
  3. concentrationthe filtrate was concentrated
  4. customThe raw product was purified

Quellen und Nachweise

ORD-Eintrag
ord-ee229ad94a7a4d8a899d0ed9eefad31b
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05965059

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