Hydrochloric Acid → HCID 21840019, Verbindung

HRID 1739012Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1739012
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[CH:21]=2)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:10](=[O:27])[CH2:9]1)=O)(C)(C)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[O:27]=[C:10]1[C:11]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[CH:21]=2)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 54555641HCID 54555641, Verbindung

Produkt 1

HCID 21840019HCID 21840019, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a cold (0° C.) solution of ethyl N-tert-butoxycarbonyl-3-oxo-4-(3-methylbenzyl)piperidine-4-carboxylate (1.55 g, 4.13 mmol) in ethyl acetate (75 mL), a stream of anhydrous hydrogen chloride gas was bubbled for 20 min. The resultant mixture was stirred at 0° C. for 1 h, purged with argon for 10 min., and concentrated under vacuum to provide the title compound as white solid.

Aufarbeitung

  1. custompurged with argon for 10 min.
  2. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-c40320dd57a642adb3ef197b03481f29
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05965578

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