Trimethyl phosphonoacetate → Methyl 3-methoxy-4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]cinnamate

HRID 1739045Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1739045
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH2:12][C:13]1[N:14]=[C:15]([C:19]2[O:20][CH:21]=[CH:22][CH:23]=2)[O:16][C:17]=1[CH3:18])[CH:6]=O.[CH3:24][O:25][C:26]([CH2:28]P(OC)(OC)=O)=[O:27]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH2:12][C:13]1[N:14]=[C:15]([C:19]2[O:20][CH:21]=[CH:22][CH:23]=2)[O:16][C:17]=1[CH3:18])[CH:6]=[CH:28][C:26]([O:25][CH3:24])=[O:27]

Komponenten

3

Edukt 2

HCID 80029Trimethyl phosphonoacetateHCID 223446304-[2-(2-Furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzaldehyde

Produkt 1

HCID 54365390Methyl 3-methoxy-4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]cinnamateAusbeute 90 %

Versuchsvorschrift

According to the same manner as that described in Reference Example 1, 3-methoxy-4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]benzaldehyde was reacted with trimethyl phosphonoacetate to give methyl 3-methoxy-4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]cinnamate (yield: 90%). This product was recrystallized from dichloromethane-diethyl ether. Colorless prisms, mp: 129-130° C.

Quellen und Nachweise

ORD-Eintrag
ord-3e6186fa4bc24f01a74e685f0a539e11
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05965589

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