2-Hydroxy-5-methylbenzyl alcohol → Benzaldehyde, 2-hydroxy-5-methyl-

HRID 1739486

Reaktionsgleichung

Reaktionsgleichung von HRID 1739486
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:4]=1[OH:10]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[OH:10][C:4]1[CH:5]=[CH:6][C:7]([CH3:9])=[CH:8][C:3]=1[CH:2]=[O:1]

Komponenten

4

Edukt 1

HCID 2574522-Hydroxy-5-methylbenzyl alcohol

Produkt 1

HCID 69184Benzaldehyde, 2-hydroxy-5-methyl-Ausbeute 20,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

2-Hydroxymethyl-4-methylphenol (3.1 g, 22.4 mMol) was dissolved in CHCl3 (95 ml). The solution was treated with manganese dioxide (8.7 g, 100 mmol) and the reaction stirred at ambient temperature overnight under an argon atmosphere. The reaction was then filtered through Celite and the solvent evaporated. The residue was subjected to chromatography (eluant: ethyl ether/hexane) to give 2-hydroxy-5-methylbenzaldehyde as a pale green solid (0.63 g, 20.7%).

Aufarbeitung

  1. filtrationThe reaction was then filtered through Celite
  2. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d860a9483f7040eca836722a1bc22f20
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05965741

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