1,4-Dioxane → 1-(2-(2-Propynyloxy)ethyl)piperazine dihydrochloride
Reaktionsgleichung
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15]CC#C)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19].O1[CH2:25][CH2:24][O:23]CC1.O1CCOC[CH2:27]1>>[ClH:19].[ClH:19].[CH2:24]([O:23][CH2:15][CH2:14][N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:25]#[CH:27]Komponenten
4
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
To a solution of 10.70 g of 1-tert-butoxycarbonyl-4-(2-(2-propynyl)ethyl)piperazine in 1,4-dioxane was added 4N hydrochloric acid/1,4-dioxane, and the mixture was stirred at 60° C. After completion of the reaction, the mixture was concentrated and diethyl ether was added. The solid was collected by filtration and dried to give 11.83 g of the title compound.